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Some signs of B12 deficiency: Anemia (megaloblastic) Gastrointestinal lesions Poor nerve health Numbness/tingling sensation Memory loss, disorientation Weakness Personality and mood changes (including depression, dementia) Difficulty waking Some risks for B12 deficiency: Vegetarian, vegan, or low animal product diets Aging Males Caucasian and Latin American descent Malabsorption issues Pregnancy Alcoholism Small bowel resection or stomach surgery What is Vitamin D3

Supplements are not regulated by the FDA as rigorously as other OTC medications, however, so there is no guarantee about their content and efficacy

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Notably, nicotinamide N-methyltransferase (NNMT) has recently surfaced as a promising therapeutic target for addressing MetS