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The endothelial cell-based in-vitro model of the BBB was also found to experience an increase in ROS after exposure to ART combination, and the resulting cytotoxicity was attributed to mitochondrial and oxidative stress mechanisms since mitochondrial potential and ATP levels were altered as well as the levels of glutathione and malondialdehyde (Manda et al

10.1016/j.clineuro.2016.07.011 Clin

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For instance, individuals found to have a GST mutation might be advised to avoid certain environmental carcinogens, such as cigarette smoke, or might be more closely monitored for the early detection of certain types of cancer