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It was first discovered in the early 1970's, where Loren Pickart found out that the complex positively affected older liver cells, making them function like liver cells of much younger individuals

Because MTHFR gene variations impair the bodys ability to convert B vitamins, methylated forms of B vitamins are considered the most bioavailable as they dont need any conversion by the body Consider high doses: you might need significant doses of methylcobalamin to treat a deficiency

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The search included meta-analyses, randomized controlled trials, clinical trials, and reviews