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For example, it induces Nod-like receptor protein 3 (NLRP3) inflammatory vesicle activation and IL-18 secretion in colonic epithelial cells, promotes neutrophil recruitment to sites of inflammation, and enhances the differentiation and suppressive function of FOXP3+ regulatory T (regulatory T, Treg) cells ( in vitro and in vivo ( Overall, the diverse molecular targets of SCFAs illustrate that different SCFAs in different tissues can target immune and non-immune cells, modulate immunity in the gut and distal organs, and potentially protect against immune-mediated diseases

7.3 Immune system activation and chronic inflammation The translocation of gut-derived endotoxins activates the innate immune system, especially via TLR4 and TNF signaling pathways

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