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On the other hand, some AA supplements were discussed, such as glycine [29, 30] and histidine [54]

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Specifically, hASC-EVs activate the PI3K/Akt pathway and promote Nrf2 nuclear translocation via p62-mediated KEAP1 degradation, thereby enhancing antioxidant defense [153]

FIGURE 1 Given the scope of this review, we will summarize insulin actions on non-renal target organs, but detailed information is available in recent reviews (Gancheva et al., 2018