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Daratumumab monotherapy in patients with treatment-refractory multiple myeloma (SIRIUS): an open-label, randomised, phase 2 trial

doi:10.1046/j.1365-2125.2001.01305.x

What is measured in these rats and mice (and occasionally in small groups of human volunteers) is often not a hard endpoint like muscle strength or weight loss, but surrogate biomarkers: molecules in the blood that have an indirect link to a hard endpoint

The purpose of these injections is to deliver medication, usually a combination of a local anesthetic and a steroid anti-inflammatory medication, to a targeted tissue (like joint, nerve or disc), suspected or known to be a source of pain