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The route of administration in all published studies has been intraperitoneal injection in mice

Royal College of Physicians

PE-22-28 Safety Considerations# PE-22-28's safety profile is less burdened by mechanism-specific concerns: TREK-1 channels are expressed throughout the body (brain, heart, vasculature, gastrointestinal tract), so systemic TREK-1 blockade could theoretically affect cardiovascular function, pain sensation, and gastrointestinal motility

Tesamorelin is a synthetic analog of human growth hormone-releasing hormone (GHRH), consisting of 44 amino acids with a structural modification at its N-terminal end