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Class 1 appears predominantly driven by physiological burden with reactive psychological distress, whereas Class 3 represents a convergence of medication effects, neurocognitive disturbances, and undiagnosed sleep pathology

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You X, Li Z, Ma K, Zhang C, Chen X, Wang G, Yang L, Dong M, Rui X, Zhang Q, Li W (2020) Structural characterization and immunomodulatory activity of an exopolysaccharide produced by Lactobacillus helveticus LZ-R-5

Cardiac sympathetic denervation, detectable via 123 I-MIBG scintigraphy, is strongly associated with disease progression (Grosu et al., 2023)