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Prolonged hyperactivation of the hypothalamic-pituitary-adrenal axis, indicated by abnormally high cortisol levels, is also observed

It is naturally produced in nearly every cell of the body and plays a central role in: Neutralizing free radicals that cause oxidative stress and cellular damage Supporting liver detoxification , particularly in Phase II detox pathways Regulating the immune system , helping balance inflammation and defense Repairing DNA and proteins , essential for anti-aging and longevity Because of its central role in cellular defense, glutathione is often called the master antioxidant. However, levels can drop due to aging, chronic stress, poor diet, toxin exposure, or genetic variants like MTHFR , which can limit glutathione recycling

doi: 10.1126/science.1162667

doi: 10.1016/j.btre.2024.e00851