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Peer-reviewed GHK-Cu research includes a substantial mechanistic literature (cell-culture, gene-expression-profile, and animal studies), a smaller clinical literature in topical-skincare applications including the Miller 2006 controlled post-laser-resurfacing trial, and limited published human data on injectable or oral administration routes

Dr Pickart's own company sold topical formulations

Moreover, determining the precise range of copper levels that cause selective cytotoxicity to cancer cells for the translation of personalized copper-based strategies for targeting specific cell death pathways is of importance

This protocol reduces total peptide usage by about 15% while preserving efficacy better than uninterrupted daily administration