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176 In an orthotopic breast cancer mouse model, knocking down ATP7A reduced LOX activity and reduced the recruitment of myeloid cells to the lungs, suppressing tumor growth and metastasis

However, there are dynamic scaffold-based 3D models used to study flow shear stress, such as polydimethylsiloxane (PDMS) only models, and others that combine the hydrogel cell culturing techniques with more complex microfluidic systems, namely PDMS-derived, PDMS-hydrogel hybrids, or pure hydrogel models [259]

Phospholipase C (PLC) Pathway : PLC enzymes cleave the phosphodiester bond of PC, generating DAG and a phosphorylated head group