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The predicted binding mode of 1j indicates the C5-amino substituent forms hydrogen bonding interaction with the carboxylic backbone of the Ser201 residue and a hydrophobic bonding with the Ser213 residue unlike the NCA amide group that is in hydrogen bonding distance from with the NNMT Ser213 residue

This small molecule peptide functions as a selective nicotinamide N-methyltransferase (NNMT) inhibitor, targeting cellular metabolism at its source

Enhanced Fat Loss AOD-9604 targets and reduces stubborn fat deposits, helping to accelerate weight loss and improve body composition

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