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Two compounds were found to be highly effective antifungal agents in cryptococcosis100 by specifically targeting the synthesis of the fungal sphingolipid glucosylceramide (GluCer): N'-(3- bromo- 4-hydroxybenzylidene)-2-methylbenzohydrazide (BHBM) and its derivative 3-bromo- N'-(3- bromo- 4-hydroxybenzylidene)benzohydrazide (B0)

Additionally, Karin et al.'s research indicates that the activation of T-cells hinges on glycolysis that perpetually generates lactate, and the accumulation of lactate in cells throws T-cells' metabolism into disorder and retards their activation [99]

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Fructose-1,6-bisphosphate prevents pregnancy loss by inducing decidual COX-2(+) macrophage differentiation