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However, the effective use of BLM in chemotherapy remains limited, as it precipitates dose-dependent interstitial pneumonia, resulting in pulmonary fibrosis in at least 10% of individuals treated with BLM, ultimately leading to irreversible lung structural damage (Yen et al., 2005

Methyl THF is the most common form of folate in tissues and the plasma and serves as the methyl group donor in the methyl THF-homocysteine S-methyltransferase reaction involving remethylation of homocysteine to methionine ( The deficiency of MTHFR enzyme causes an increase in the concentration of homocysteine and methionine, resulting in severe neurological phenotypes

Both treatments decreased the SN reticulata (SNR) firing rate compared to that in the HP group

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