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However, the reduction in contractility observed in the presence of tempol in the AG (44% reduction, compared to the absence) may be due to the conversion of O 2 into H 2 O 2 stimulated by this mimetic, thereby reducing the amount of O 2 and its availability for ONOO formation, which is produced through its reaction with NO , ultimately decreasing tracheal hyperresponsiveness

It is currently being investigated in phase 3 trials, and results from a phase 2 trial published in the New England Journal of Medicine are show great promise

2024 Jul 15];103

However, excess ROS induces inflammatory cell infiltration and macrophage polarization through mitochondrial homeostasis disruption and production of pro-inflammatory factors, forming a vicious cycle of central nerve inflammation and ROS production, further aggravating inflammation and the formation of glial cell scar