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CassottaAMikolVBertrandTPouzieuxSLe ParcJFerrariPet alA single T cell epitope drives the neutralizing anti-drug antibody response to natalizumab in multiple sclerosis patients

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Conclusions It is clear that after many years, and considerable attention, the understanding of ADE of disease after either vaccination or administration of antiviral antibodies is insufficient to confidently predict that a given immune intervention for a viral infection will have negative outcomes in humans

Studies in autoimmune thyroid models show reduced CD4+CD25+Foxp3+ cell numbers and decreased Foxp3 mRNA expression in splenocytes