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The intensification of the inflammatory response is closely related to the activation of the Toll-like receptor 4 (TLR4)/Krppel-like factor 5 (KLF5)/nuclear factor-kappa B (NF-B) signaling pathway (Figure 1)

However, the studies' concentration in certain countries may indicate areas of focused research expertise or specific regional interests (Figure 2)

The in vitro BBB models were treated likewise

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