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A randomized, double-blind, multicenter clinical trial investigated the efficacy and safety of Ginkgo biloba dropping pill (GBDP) as an adjunctive treatment to standard therapy in a cohort of 72 SAP patients presenting with depression over a duration of 12 weeks (70)

Structurally, the BBB is highly lipophilic and composed of cerebrovascular endothelial cells, astrocytes, pericytes, neuronal cells, immune cells, microglial cells, glial cells, smooth muscle cells, and a basement membrane (Fig

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The Fh8 presents two EF-hand motifs, and it was characterized as a Ca 2+ sensor protein : when calcium binds, the Fh8 switches from a closed (apo-state) to an open (calcium-loaded state) conformation due to the reorientation of the four helices, exposing a large hydrophobic region that acts as a target-binding surface (Fraga et al., 2010)