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Features and mechanisms of ferroptosis Features of ferroptosis In 2012, ferroptosis was first termed by Stockwell Lab to define RAS-selective lethal small-molecule erastin-induced human fibrosarcoma cell death [23], which is iron-dependent, and morphologically and biochemically distinct from apoptosis, necrosis, autophagy-dependent cell death, and pyroptosis (Table 1)

In the choline-methionine deficient diet rats, a model of NAFLD, sobetirome prevented and reverted choline-methionine deficient-induced fat accumulation, ameliorated steatohepatitis and promoted regression to pre-existing fat accumulation without significant side effects on heart rate