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Nishida Y, Ishizawa J, Ayoub E, Patsilevas T, Ostermann L, Heinz Montoya R, Muftuoglu M, Ruvolo V, Mak PY, Tao W, Carter BZ, Kojima K, Daver N, Lesegretain A, Seki T, Shacham S, Konopleva M, and Andreeff M

Treatment of pancreatic cancer patient-derived xenograft panel with metabolic inhibitors reveals efficacy of phenformin

Protein carbonylation (PC), a major hallmark of OS, is an irreversible modification that can be generated by covalent addition of lipid peroxidation products known as reactive lipid aldehydes (RLAs) into proteins, resulting in protein inactivation, misfolding, aggregation, degradation and formation of neo-antigens

Documented laboratory research contexts include: Analytical investigation of NNMT-related metabolic and methylation pathways in experimental model systems Evaluation of enzymeinhibitor interactions involving nicotinamide metabolism under controlled laboratory conditions Molecular pathway mapping associated with NAD-related metabolic signaling in research environments Analytical reference use in chromatographic method development and compound characterization Stability assessment and purity verification within non-clinical laboratory workflows All referenced applications are strictly confined to controlled laboratory research and non-clinical experimental use