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In an exception to the catabolism of the BR-Chitosan at the tumor site to release the internal hypoxia-activated prodrug HAPTH-302, it also exhibited intrinsic oxygen-consuming properties in the tumor region in the presence of overexpression of ROS, including H 2 O 2 , which greatly increased the degree of hypoxia around the tumor tissues and converted HAPTH-302 from nontoxic to toxic in a hypoxic environment, exerting selective antitumor effects