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doi: 10.2174/1570159X20666220222150811 44

Oxidants spontaneously released by alveolar macrophages of cigarette smokers can inactivate the active site of alpha 1-antitrypsin, rendering it ineffective as an inhibitor of neutrophil elastase

Targeting Methionine Metabolism or Sensors for Novel Antifungals The key position that methionine metabolism holds, suggests opportunities to develop novel antifungal drugs (summarized in Figure 2)