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Pycnogenol attenuates the release of proinflammatory cytokines and expression of perilipin 2 in lipopolysaccharide-stimulated microglia in part via inhibition of NF-B and AP-1 activation

It is widely applied in industries such as swimming pool and drinking water sanitation, aquaculture, and consumer chemicals ( The toxic effects of TCCA are mainly attributed to the high concentration of chlorine gas released during its decomposition ( Clinically, low-level exposure to chlorine gas may be asymptomatic, while higher concentrations can induce symptoms such as cough, chest tightness, mediastinal oscillation, acute respiratory distress syndrome (ARDS), respiratory failure, and even cardiopulmonary arrest ( Corticosteroids, potent anti-inflammatory agents, inhibit the synthesis of proinflammatory mediators and modulate systemic immune responses ( 2 Case presentation A 49-year-old male, engaged in poultry greenhouse disinfection, was resting in a sealed 10-square-meter room containing TCCA powder

This establishes a self-perpetuating cycle in which inflammation further enhances ROS production, exacerbating oxidative stress and tissue damage [4, 5]