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Trends in vitamin A, C, D, E, K supplement prescriptions from military treatment facilities: 2007 to 2011

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4.2.1 NF1-associated OPG displays temporal and spatial specificity and is highly dependent on cell-of-origin and MAPK pathway activation The mTOR pathway had been well-implicated in NF1-associated disorders (85, 95, 96), and it was shown that MAPK pathway activation in NF1 -deficient astrocytes resulted from RAS hyperactivation (78, 85)