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Description

First-line pembrolizumab and trastuzumab in HER2-positive oesophageal, gastric, or gastro-oesophageal junction cancer: an open-label, single-arm, phase 2 trial

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In all three groups, 60% of participants had a low education level (elementary school only), 47% were smokers or ex-smokers, only 3% drank alcohol, 73% had hypertension and 52% had altered glucose (Table 2)

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Additionally, ROS can activate Ras proteins, which, as GTPase switch proteins, activate Raf kinase and initiate a MAPK cascade, activating downstream kinases MEK and ERK

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