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In addition to the previous, it increases the expression of VEGF, iNOS, p21, p53 mutation, and bcl2 genes

Interestingly, Fer-1-treated monocytes displayed significantly lower frequency of cells expressing pro-IL-1 which was not seen in cultures treated with MCC950 ( Figure 6C ), consistent with its effect downstream of the signal 2 for NLRP3 activation

This is essential for immune cells which may encounter regions of hypoxia in tissue microenvironments

Free Radic Biol Med (2012) 52:9931002.10.1016/j.freeradbiomed.2011.12.019 28 ZhangLWangSWangtaoYWangJWangLJiangSet alUpregulation of GRP78 and GRP94 and its function in chemotherapy resistance to VP-16 in human lung cancer cell line SK-MES-1