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Second, the MCD model does not robustly activate de novo lipogenesis, and GADD45 may influence lipid accumulation via alternative pathways, such as fatty acid uptake or oxidation, which were not functionally explored

Anti-obesity drugs target either central nervous system pathways, which regulate sensations of satiety and fullness, or peripheral modulators of digestion, metabolism and lipogenesis

And the treatment depends entirely on the reason

Unlike caloric restriction alone, which often results in both fat and muscle loss, the peptides mechanism specifically targets adipose tissue without promoting protein catabolism