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Folic acid, folinic acid, 5-methyltetrahydrofolate supplementation for mutations that affect epigenesis

It boosts the anti-inflammatory ones, relieving common IBD symptoms

J Clin Investig 117:16581669 Hillson JL, Furst DE (1997) Pharmacology and pharmacokinetics of methotrexate in rheumatic disease: practical issues in treatment and design