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One key strategy for targeting nanoparticles (NPs) to specific brain regions is by exploiting the alterations in the neurovascular units and the resulting changes in the local microenvironment associated with specific CNS disorders ( 6 Targeting specific cell types in the brain by nanoparticles Astrocytes play a crucial role in maintaining cerebral homeostasis by regulating the BBB, recycling neurotransmitters, remodelling synapses, and balancing ion concentrations (78)

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