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In addition, the combination of these two agents, carmustine and selenite, triggered apoptosis in prostate cancer cells

Furthermore, loss of amylo-1,6-glucosidase (AGL), a glycogen debranching enzyme, leads to elevated SHMT2 levels, which in turn increases glycine and purine nucleotide synthesis and further supports tumor cell proliferation (78)

Compared to oxygen, sulfur contains an available d-orbital for bond formation, has a larger radius, and is less electronegative (2.58 for sulfur, compared to oxygen at 3.44 on the Pauling scale)