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Obesity has been observed to shift the asthmatic immune response away from the classic T2 high eosinophilic inflammation towards a T2 low phenotype, promoting a more Th1 and Th17-skewed profile, contributing to cell-mediated immunity and sustained inflammation [39]

The investigators thank: Dr

Muscle-derived lactic acid is converted into alanine, transported to the liver, converted back to lactic acid and then used in de novo gluconeogenesis to synthesize glucose (see Figure 1)