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Int J Neurosci 121(9):497502

Inflammopharmacology 29, 16691681

Following menopause, serum E2 levels reduce from premenopausal levels of 5-35 ng/dl to ~1.3 ng/dl (50,51)

In clinical advancement, strategies with more realistic value include local delivery or use as adjuvant therapy, rather than relying on long-term systemic exposure