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Receptors of GDF-15 are present in the appetite regulation site and when antibodies anti-GDF-15 were effective in controlling nausea and anorexia in some phase 1 clinical trials (51)

Neuroinflammation Neuronal loss in PD is associated with chronic neuroinflammation, which is controlled primarily by microglia, the major resident immune cells in the brain (Perry, 2012)

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