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A responsible plan improves outcomes and reduces preventable complications

B12 is a required cofactor for DNA synthesis without enough of it, cells can't replicate efficiently

Assuming oral bioavailability of ~1% with current formulations that have been FDA-approved compared to injections of the same peptide, the cost-of-goods argument becomes unsustainable for most candidates that might be considered for conversion to the oral route

Together, these findings indicate that exon 10 is an important domain to maintain G6PD structural integrity and functionality, and mutations in this region of the enzyme commonly result in the most severe form of deficiency