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Other genetic factors, such as those related to GSTM1 (glutathione transferase) can reduce your ability to eliminate harmful free radicals made from certain hydroxylated estrogens

the minority of persons who have CNSHA are referred to as having rare, sporadic, or severe G6PD deficiency (corresponding to class I)

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High concentrations and prolonged exposure to ROS causes extensive damage to various integral cellular biomolecules (Figure 1B), including proteins, lipids and nucleic acids, which ultimately hampers multiple cellular functions (49, 88)