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Hif-2alpha, but not hif-1alpha, promotes iron absorption in mice

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The mechanistic rationale for stacking MOTS-c 5-Amino-1MQ holds regardless of administration route, but practical bioavailability constraints may require adjustment

( i-k ) Immunoblot of the indicated proteins in FT282 cells with empty vector (EV) or MYC overexpression treated with IDH1 inhibitor ( i ), cultured under glutamine starvation (GS) ( j ), or treated with mildronate ( k ) and supplemented with KG, l-carnitine, or O-acetyl-l-carnitine