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While levodopa is the most effective drug, it has its limitations: over time, the response to treatment decreases, and increasing the dose becomes necessary

In one study, both GSH and GSSG achieved a skin lightening effect though it takes a few weeks to develop

However, these genetic associations are inconsistent as studies typically have quality-control issues (56)

The strongest research base is still preclinical rather than large-scale human randomized trials, but the consistency of the findings is one reason BPC-157 has gained so much attention