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There is also a twofold increased rate of colorectal cancer in both sexes and a twofold increased risk of breast cancer in women

Lactate suppresses macrophage pro-inflammatory response to lps stimulation by inhibition of yap and nf-b activation via gpr81-mediated signaling

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Given the presence of both mandatory major criteria (polyneuropathy and monoclonal plasma cell proliferative disorder), at least one other major criteria (sclerotic bone lesions), and at least one minor criteria (skin changes, extravascular volume overload, endocrinopathy), as well as other associations (vitamin B12 deficiency), the patient was diagnosed with POEMS syndrome