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A first prospective, randomized, placebo-controlled, phase-III study could demonstrate in high risk patients after myocardial infarction that specific neutralization of IL-1 by canakinumab (CANTOS trial) can significantly reduce cardiovascular mortality (7)

These include (i) four ionotropic glutamate receptor genes with sodium transport function linked to insecticide resistance 40 , and a probable glutathione peroxidase 2 gene with oxidative stress function linked to insecticide resistance 41