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Damage-associated molecular patterns (DAMPs) activate pattern recognition receptors, triggering the substantial release of pro-inflammatory cytokines (including IL-6, TNF-, and IL-1) and CXC chemokines 6

Notably, IL-6 not only modulates hepcidin to affect the release of stored iron from ATMs and intestinal absorption, but also reduces transferrin expression and aggravates iron accumulation by promoting hepcidin production