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As the only bifunctional enzyme in the ARS family, EPRS activates the WNT/GSK-3/-catenin signaling pathway and stimulates the accumulation of -catenin in the nucleus by directly binding to SCYL2 (SCY1-like protein 2), promoting cancer cell proliferation

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PMID 9733495) established ipamorelin as a selective GH secretagogue without significant elevation of ACTH, cortisol, or prolactin distinguishing it from older GHRPs