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The mechanism of coupling between electron transfer and proton translocation in respiratory complex I

Targeting autophagy has been particularly challenging due to its context-dependent dual role, with non-specific inhibitors such as chloroquine showing limited efficacy, highlighting the need for more precise agents (213)

The dual nature of ROS is evident in premalignant and malignant cells at all stages of tumor development, including proliferation, migration/invasion, angiogenesis, inflammation, immune evasion, and metastasis

This underscores its status as a non-approved compound outside legitimate regulated sport