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5 Disruption of the neuroendocrine network and the local biochemical microenvironment The pathological microenvironment of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) involves not only inflammatory-immune crosstalk and oxidative stress, but alterations in local biochemical components and dysregulation of the neuroendocrine network also represent crucial links in the impairment of sperm development

Wang L , Tsutsumi S, Kawaguchi T, Nagasaki K, Tatsuno K, Yamamoto S, Sang F, Sonoda K, Sugawara M, Saiura A, Hirono S, Yamaue H, Miki Y, Isomura M, Totoki Y, Nagae G, Isagawa T, Ueda H, Murayama-Hosokawa S, Shibata T, Sakamoto H, Kanai Y, Kaneda A, Noda T, Aburatani H

68 Studies concluded a connection between genetic variations and endometriosis

Using a conventional double knockout mouse model for the Gstp1 and Gstp2 genes, we found that the lack of GSTP1/P2 reduced the rate of DNA replication and mitotic index during the first wave of hepatocyte proliferation