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Findings suggest it modulates extracellular matrix remodeling and fibrosis, in part through transforming growth factor-beta (TGF-?) signaling pathways [7]

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Interestingly PUMA interacts with HER2 and is phosphorylated at Y152 and Y172 this phosphorylation increased degradation of the protein and reduces apoptosis induction ( BAX/BAK BAX and BAK form pores in the outer mitochondrial membrane and drive mitochondrial permeabilization (Wei et al., 2001

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To probe the structurally observed PG-binding site on the back of the head domain, we constructed mutant variants R155A/Q, D157A/N, H196A/Q and Y201F

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