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A toxicity study in rats administered oral GABA (500-2500 mg/kg/day) for 13 weeks and found no significant abnormalities in behavior, weight gain, or blood indices including general chemistries, glucose, renal function, hematology and liver function

Measures Primary outcome Primary outcome was measured with CARS 34 , which has been used to assess the occurrence and severity of clinical symptoms of ASD and to delineate disease trajectory and monitor treatment efficacy

G6PD testing for neonates is often unavailable in malaria-affected communities, and the result may be difficult to interpret because of the haematological dynamics at birth 23,24

Surprisingly, both Grx1 and Grx2 have shown 64 % similarity, Grx1 mutants were not impacted whereas 5 % wild-type activity affected Grx2 mutants, which indicated that Grx2 played the leading role