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Celastrol suppresses tumours by covalently targeting PRDX in both gastric [62] and colorectal [63] cancers

10.18240/ijo.2018.04.04 41 HellinenL.HagstromM.KnuutilaH.RuponenM.UrttiA.ReinisaloM

Although lower temperatures may transiently improve tumor oxygenation and thus enhance radiation response, higher temperatures (above 42 C) can damage vascular structures, leading to increased hypoxia post-treatment, which may paradoxically protect the tumors from radiation, as indicated in ref