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Biofactors 48(3):611633 Al-Khayri JM, Sahana GR, Nagella P, Joseph BV, Alessa FM, Al-Mssallem MQ (2022) Flavonoids as potential anti-inflammatory molecules: a review

Altered GH-IGF-1 axis in severe obese subjects is reversed after bariatric surgery-induced weight loss and related with low-grade chronic inflammation

They not only modulated hepatic inflammation, hepatoprotection, and glucose-lipid metabolism but also exhibited potential mechanisms, including gut microbiota regulation, anti-hepatic fibrosis, and metabolic modulation

Butyrate is used by colonocytes to generate energy, stabilizes hypoxia-inducible factor to maintain the anaerobic environment in the gut, maintains gut barrier integrity by regulating Claudin-1 and synaptopodin expression, limits pro-inflammatory cytokines (IL-6, IL-12), and inhibits oncogenic pathways (Akt/ERK, Wnt, and TGF- signaling)