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10.1093/nar/gky310 13 DownsJ

Interestingly, several studies showed that cytokines and stress stimuli such as TNF-, interleukins, FAS ligand, heat shock, UV irradiation and also stressors that deplete glutathione such as ROS and 4HNE can activate sphingomyelinase, which leads to increased ceramide production 58,59,60

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In the present study, we found significant differences in GST protein levels between MCI and AD patients after 1 year of follow-up, suggesting that GST protein levels may change more rapidly in the later stages of the disease