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Specifically, leptin has been identified as a factor that induces MUC5AC expression by activating extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinases (MAPKs) ( MUC5AC and MUC5B expression through the ERK1/2, p38, and nuclear factor kappa B (NF-B) signaling pathways ( MUC5AC and MUC5B are associated with goblet cell metaplasia ( In summary, obesity is linked to a genetic predisposition and genes associated with airway remodeling

Deletions of NRXN1 (neurexin-1) predispose to a wide spectrum of developmental disorders

It is also a vital biomarker for early urinary tract infections (UTI) diagnosis, as bacteria like E