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Methods: We developed a biomimetic autophagy degradation peptide (MNP-PDL1) using the lysosomal autophagy system in conjunction with biomimetic membrane technology, which consists of a PD-L1-binding sequence, a PEG3 linker, and a target lysosomal chaperone protein recognition sequence (CIP), which can localize the target protein, PD-L1, to the lysosome for degradation

Am J Physiol Endocrinol Metab 299:E364E373 Youm Y-H, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, DAgostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD (2015) Ketone body -hydroxybutyrate blocks the NLRP3 inflammasome-mediated inflammatory disease